Cortisone Acetate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** The acetate salt form of cortisone, a synthetic or semisynthetic analog of the naturally occurring cortisone hormone produced by the adrenal glands with anti-inflammatory and immunomodulating properties. Cortisone acetate diffuses through the cell membrane and binds to nuclear glucocorticoid receptors. The receptor-ligand complex binds to promotor regions of certain genes and initiates RNA transcription. This results in an induction of synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators.

**Synonyms:** - 21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione - 21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione - 6alpha,9Difluoro-11beta,17,21-trihydroxypregna-1,4- diene-3,20-dione 21-acetate 17- Butyrate - CORTISONE ACETATE - Cortisone acetate - Cortogen - Cortogen - Cortone - Cortone - Cortone acetate