A2M wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human A2M wild-type allele is located in the vicinity of 12p13.31 and is approximately 49 kb in length. This allele, which encodes alpha-2-macroglobulin protein, plays a role in various processes as a protease inhibitor. Mutations in this gene are associated with alpha-2-macroglobulin deficiency and susceptibility to Alzheimer disease.

**Synonyms:** - A2MD - Alpha-2-Macroglobulin wt Allele - CPAMD5 - FWP007 - S863-7