ATP2A2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ATP2A2 wild-type allele is located in the vicinity of 12q24.11 and is approximately 70 kb in length. This allele, which encodes sarcoplasmic/endoplasmic reticulum calcium ATPase 2 protein, is involved in the modulation of cardiac muscle contractility. Mutation of the gene is associated with both Darier disease and acrokeratosis verruciformis.

**Synonyms:** - ATP2B - ATPase, Ca++ Dependent, Slow-Twitch, Cardiac Muscle-2 Gene - ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 wt Allele - DAR - DD - SERCA2 - Sarcoplasmic Reticulum Ca(2+)-ATPase 2 Gene