NOTCH3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NOTCH3 wild-type allele is located within 19p13.2-p13.1 and is approximately 41 kb in length. This allele, which encodes neurogenic locus notch homolog protein 3, is involved in both cell-cell signaling and cell differentiation. Mutation of the gene is associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

**Synonyms:** - CADASIL - CASIL - IMF2 - Notch (Drosophila) Homolog 3 Gene - Notch 3 wt Allele - Notch Homolog 3 (Drosophila) Gene - Notch Homolog 3 Gene - Notch, Drosophila, Homolog of, 3 Gene