CYBB wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human CYBB wild-type allele is located in the vicinity of Xp21.1 and is approximately 33 kb in length. This allele, which encodes cytochrome B-245 heavy chain protein, is involved in the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with both atypical mycobacteriosis, familial, X-linked 2 and chronic granulomatous disease, X-linked.

**Synonyms:** - AMCBX2 - CGD - CGDX - Cytochrome B-245 Beta Chain wt Allele - Cytochrome B-245, Beta Polypeptide Gene - Cytochrome b(-245), Beta Subunit Gene - Cytochrome b(588), Beta Subunit Gene - GP91-1 - GP91-PHOX - NOX2 - gp91 phox