Mitogen-Activated Protein Kinase Kinase Kinase 5

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Mitogen-activated protein kinase kinase kinase 5 (1374 aa, ~155 kDa) is encoded by the human MAP3K5 gene. This protein is involved in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation.

**Synonyms:** - ASK1 - Apoptosis Signal Regulating Kinase 1 - Apoptosis Signal-Regulating Kinase 1 - EC 2.7.11.25 - MAP/ERK Kinase Kinase 5 - MAP3K5 - MAPK/ERK Kinase Kinase 5 - MEK Kinase 5