Toxic Shock Syndrome Toxin-1

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor

**Definition:** Staphylococcal toxic shock syndrome toxin 1. A superantigen with the potential to suppress plasma cell differentiation and antibody responsiveness. Potent pyrogen, induces T lymphocyte proliferation, requiring interleukin 1 release from macrophages, suppresses immunoglobulin production, enhances endotoxin shock, and enhances hypersensitivity skin reactions. Causes staphylococcal toxic shock syndrome (TSS).

**Synonyms:** - TSST-1