BCR-ABL TKI-Resistant Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A molecular genetic abnormality in the kinase domain of the BCR-ABL fusion gene that results in resistance to tyrosine kinase inhibitors.

**Synonyms:** - BCR-ABL Tyrosine Kinase Inhibitor-Resistant Mutation - BCR-ABL1 TKI-Resistant Mutation - BCR-ABL1 Tyrosine Kinase Inhibitor-Resistant Mutation - BCR/ABL TKI-Resistant Mutation - BCR/ABL1 TKI-Resistant Mutation - BCR/ABL1 Tyrosine Kinase Inhibitor-Resistant Mutation - BCR::ABL TKI-Resistant Mutation