Genistein

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)

**Synonyms:** - 4',5, 7-Trihydroxyisoflavone - 4',5,7-Trihydroxyisoflavone - 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one - GENISTEIN - Genestein - Genisteol - Genisteol - Prunetol - Prunetol - genistein