Fluorine F 18 Dasatinib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A radioconjugate composed of a derivative of the multi-targeted kinase inhibitor dasatinib conjugated to the radioisotope fluorine F 18, with potential imaging activity during positron emission tomography (PET). Upon administration of fluorine F 18 dasatinib, dasatinib targets and binds to Bcr/Abl, SRC-family protein-tyrosine kinases, c-Kit and platelet-derived growth factor receptor (PDGFR). Upon binding, the fluorine F 18 moiety allows PET imaging of tumor cells and can be used as a tracer for the biodistribution of dasatinib.

**Synonyms:** - F-SKI249380 - FLUORO-DASATINIB F-18 - Fluorine F 18 SKI-249380 - Fluorine F 18 SKI-249380 - Fluoro(F18)-Dasatinib - SKI-249380 F-18 - [18F] SKI-249380 - [18F]-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-fluoroethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide