Notch Receptor Intracellular Domain

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** The free carboxy-terminal intracellular domain (ICD) of a notch family protein, which is a product of regulated intramembrane proteolysis mediated by the gamma-secretase enzyme complex. This protein fragment is involved in transcriptional regulation of target genes.

**Synonyms:** - NICD - Neurogenic Locus Notch Homolog Protein ICD - Neurogenic Locus Notch Homolog Protein Intracellular Domain - Notch ICD - Notch Intracellular Domain