Rupitasertib

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. Upon administration, rupitasertib binds to and inhibits the activity of p70S6K and Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K pathway are frequently associated with tumorigenesis of many tumor types; targeting multiple kinases in this pathway is more efficacious than targeting a single kinase.

**Synonyms:** - M-2698 - MSC-2363318A - MSC2363318A - RUPITASERTIB - p70S6K/Akt Inhibitor M-2698 - p70S6K/Akt Inhibitor MSC2363318A