Prostaglandin E2

**Semantic type:** Organic Chemical

**Definition:** A prostaglandin with 2 double bonds that is generated by the action of prostaglandin E synthases on prostaglandin H2. Prostaglandin E2 is a mediator of active inflammation, and has important biologic effects including potent vasodilation, smooth muscle relaxation, stimulation of osteoclast-dependent bone resorption and induction of both pain and fever. It is also used as a vaginal suppository during labor to soften the cervix and promote uterine contractions.

**Synonyms:** - (5Z,11alpha,13E,15S)-11,15-Dihydroxy-9-Oxoprosta-5,13-Dien-1-Oic Acid - (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-Oxoprost-13-Enoate - (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-Oxoprosta-5,13-Dienoate - (5Z,13E,15S)-11alpha,15-Dihydroxy-9-Oxoprosta-5,13-Dien-1-Oic Acid - (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-Hydroxy-1-Octenyl))-5-Oxocyclopentyl)-5-Heptenoic Acid - (Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-Hydroxyoct-1-Enyl)-5-Oxocyclopentyl)Hept-5-Enoic Acid - 5-Heptenoic Acid, 7-(3-Hydroxy-2-(3-Hydroxy-1-Octenyl)-5-Oxocyclopentyl)- (8CI) - 7-(3-Hydroxy-2-(3-Hydroxy-1-Octenyl)-5-Oxocyclopentyl)-5-Heptenoic Acid - PGE(2) - PGE2 - Prosta-5,13-Dien-1-Oic Acid, (5Z,11-Alpha,13E,15S)-11,15-Dihydroxy-9-Oxo- - Prosta-5,13-Dien-1-Oic Acid, 11,15-Dihydroxy-9-Oxo-, (5Z,11alpha,13E,15S)- - Prostaglandin E(2)