FLG wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human FLG wild-type allele is located in the vicinity of 1q21.3 and is approximately 23 kb in length. This allele, which encodes filaggrin protein, plays a role in promoting disulfide-bond formation in intermediate filaments. Mutations in this gene are associated with ichthyosis vulgaris and with susceptibility to atopic dermatitis type 2.

**Synonyms:** - ATOD2 - Filaggrin wt Allele