Receptor-Activated SMAD

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A family of transcription factors that are activated by signaling mediated by tumor growth factor-beta (TGF-beta) superfamily ligand-receptor interactions. Once activated, R-SMADs play a role in the positive regulation of TGF-beta responsive gene expression.

**Synonyms:** - R-SMAD - R-SMADs - Receptor-Activated SMADs - Receptor-Regulated SMAD - Receptor-Regulated SMADs - rSMAD - rSMADs