AICA-Ribotide

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide

**Definition:** A ribonucleotide analog of adenosine monophosphate that is an intermediate in the synthesis of inosine monophosphate with potential cardioprotective activity. During myocardial ischemia, AICA-ribotide activates AMP-dependent protein kinase (AMPK), inhibits adenosine deaminase (ADA) and causes increased synthesis of both adenosine and adenosine triphosphate (ATP). These activities prevent calcium overload, increase AMPK-dependent glucose uptake and improve blood flow to the heart. AMPK, a protein kinase complex, regulates several cellular systems including the uptake of glucose, the beta-oxidation of fatty acids, protein synthesis, and the biogenesis of both glucose transporter 4 (GLUT4) and mitochondria. ADA is a key enzyme involved in purine metabolism.

**Synonyms:** - 1-(5'-Phosphoribosyl)-5-Amino-4-Imidazolecarboxamide - 1H-Imidazole-4-Carboxamide, 5-Amino-1-(5-O-Phosphono-Beta-D-Ribofuranosyl)- (9CI) - 5'-Phospho-Ribosyl-5-Amino-4-Imidazole Carboxamide - 5'-Phosphoribosyl-5-Amino-4-Imidazolecarboxamide - 5-Amino-1-(5-O-Phosphono-Beta-D-Ribofuranosyl)-1H-Imidazole-4-Carboxamide - 5-Amino-1-(5-Phospho-D-Ribosyl)Imidazole-4-Carboxamide - 5-Amino-4-Imidazole Carboxamide Ribonucleotide - 5-Amino-4-Imidazolecarboxamide Ribonucleoside 5'-Monophosphate - 5-Amino-4-Imidazolecarboxamide Ribotide - 5-Aminoimidazole-4-Carboxamide Ribonucleotide - 5-Phosphoribosyl-4-Carbamoyl-5-Aminoimidazole - AICA Ribonucleotide - AICA Ribotide - AICAR - Aminoimidazole Carboxamide Ribonucleotide - Imidazole-4-Carboxamide, 5-Amino-1-Beta-D-Ribofuranosyl-, 5'-(Dihydrogen Phosphate) (8CI) - ZMP - [(2R,3S,4R,5R)-5-(4-Carbamoyl-5-Aminoimidazol-1-yl)-3,4-Dihydroxyoxolan-2-yl]Methyl Dihydrogen Phosphate