Indole-3-Carbinol

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, a natural compound present in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. Indole-3-carbinol scavenges free radicals and induces various hepatic cytochrome P450 monooxygenases. Specifically, this agent induces the hepatic monooxygenase cytochrome P4501A1 (CYP1A1), resulting in increased 2-hydroxylation of estrogens and increased production of the chemoprotective estrogen 2-hydroxyestrone.

**Synonyms:** - 1H-indole-3-methanol - 3-Hydroxymethylindole - I3C - INDOLE-3-CARBINOL - Indole-3-carbinol - Indole-3-carbinol - Indole-3-carbinol - Indole-3-methanol - indole-3-carbinol