JCHAIN wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human JCHAIN wild-type allele is located the vicinity of 4q13.3 and is approximately 23 kb in length. This allele, which encodes immunoglobulin J chain protein, is involved in the joining of antibody monomer chains. Mutations in this gene are associated with both renal artery obstruction and fibromuscular dysplasia.

**Synonyms:** - IGCJ - IGJ - Immunoglobulin J Polypeptide, Linker Protein for Immunoglobulin Alpha and Mu Polypeptides Gene - JCH - Joining Chain of Multimeric IgA and IgM wt Allele