Anatabine

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An alkaloid found in low concentrations in plants in the Solanaceae family, which includes tobacco and tomato plants, with potential nicotine mimetic and anti-inflammatory activities. Following oral administration, anatabine may mimic the neurological effects of nicotine exposure. This agent may not have the addictive properties of nicotine; therefore, it may be appropriate for use in treating nicotine withdrawal symptoms during smoking cessation. Anatabine may also exert its anti-inflammatory effect by the inhibition of the signal transducer and activator of transcription 3 (STAT3) which then prevents the activation of the nuclear factor kappa B (NF-kB), which is a key regulator of proinflammatory cytokine release. Urine concentrations of anatabine can be used to assess the extent of tobacco use.

**Synonyms:** - (-)-Anatabine - (S)-1,2,3,6-Tetrahydro-2,3'-bipyridine - 1,2,3,6-Tetrahydro-2,3'-bipyridine - 2,3'-Bipyridine, 1,2,3,6-tetrahydro-, (S)- (9CI) - ANATABINE