RANBP2 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human RANBP2 wild-type allele is located in the vicinity of 2q12.3 and is approximately 66 kb in length. This allele, which encodes E3 SUMO-protein ligase RanBP2 protein, plays a role in both nuclear transport and protein SUMOylation. Mutation of the gene is associated with acute infection-induced encephalopathy 3. A chromosomal translocation t(2;2)(p23;q13) involving this gene and the ALK gene is associated with both inflammatory myofibroblastic tumor and, more rarely, myeloproliferative disorders.

**Synonyms:** - ADANE - ANE1 - IIAE3 - NUP358 - RAN Binding Protein 2 wt Allele - TRP1 - TRP2