PDE8B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PDE8B wild-type allele is located in the vicinity of 5q13.3 and is approximately 219 kb in length. This allele, which encodes high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B protein, is involved in second messenger metabolism. Mutation of the gene is associated with both autosomal dominant striatal degeneration and primary pigmented nodular adrenocortical disease 3.

**Synonyms:** - ADSD - PIG22 - PPNAD3 - Phosphodiesterase 8B wt Allele