Ex Vivo-activated Autologous Lymph Node Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** Autologous human lymph node T-lymphocytes, with potential immunostimulatory and antineoplastic activity. Upon collection of immune cells from the tumor-draining lymph node, the human lymph node lymphocytes are activated with anti-CD3/anti-CD28 microbeads, cultured with recombinant, human interleukin-2 (IL-2), expanded and isolated ex vivo. Upon reintroduction into the patient, the ex vivo-activated autologous lymph node lymphocytes recognize and lyse the tumor cells.

**Synonyms:** - X-ACT - X-ACT Autologous Lymph Node Lymphocytes