UHRF1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human UHRF1 wild-type allele is located in the vicinity of 19p13.3 and is approximately 59 kb in length. This allele, which encodes E3 ubiquitin-protein ligase UHRF1 protein, plays a role in both protein ubiquitination and epigenetic silencing of gene transcription. Aberrant expression of the gene is associated with many neoplastic diseases.

**Synonyms:** - FLJ21925 - ICBP90 - Np95 - RNF106 - Ubiquitin-Like With PHD and Ring Finger Domains 1 wt Allele - Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 Gene - hNP95 - hUHRF1 - huNp95