TMPRSS2/ETV5 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(3;21)(q28;q22) which fuses either the 5' untranslated region or the 5' end including exons 1 and 2 of the TMPRSS2 gene with exon 2 of the ETV5 gene. This rearrangement is associated with prostate carcinoma and androgen-dependent expression of this fusion gene results in overexpression of ETS translocation variant 5 protein activity.

**Synonyms:** - TMPRSS2-ETV5 Fusion Gene - TMPRSS2::ETV5 Fusion Gene