TMPRSS2/ETV4 Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(17;21)(q21;q22) which fuses the 5' untranslated region of the TMPRSS2 gene upstream of exon 3 of the ETV4 gene. This rearrangement is associated with prostate carcinoma and androgen-dependent expression of this fusion gene results in overexpression of ETS translocation variant 4 protein activity.

**Synonyms:** - TMPRSS2-ETV4 Fusion Gene - TMPRSS2::ETV4 Fusion Gene