N-Methylformamide

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A water-soluble organic solvent. As an adjuvant antineoplastic agent, N-methylformamide depletes cellular glutathione, a key molecule involved in the antioxidation of reactive oxygen species (ROS) and other free radicals, thereby enhancing ionizing radiation-induced DNA cross-linking in and terminal differentiation of tumor cells. (NCI04)

**Synonyms:** - EK 7011 - EK 7011 - Formamide, N-methyl - Monomethylformamide - N-METHYLFORMAMIDE - NMF - X 188 - X 188 - formylmethylamine - monomethylformamide