Fluorine F 18 Piflufolastat

**Semantic type:** Pharmacologic Substance

**Definition:** A urea-based radiotracer composed of the prostate specific membrane antigen (PSMA) targeting agent DCFPyL and labeled with the positron-emitting isotope, fluorine F 18, that can potentially be used for positron emitting tomography (PET) imaging. Upon administration of fluorine F piflufolastat, piflufolastat binds to PSMA expressed on tumor cells. The fluorine F 18 moiety facilitates PET imaging of PSMA-expressing tumor cells. PSMA, a cell-surface antigen, is abundantly present on the surface of prostate cancer cells and on the neovasculature of most solid tumors.

**Synonyms:** - 18F-DCFPYL - 18F-DCFPyL - 2-(3-(1-Carboxy-5-((6-(18f)fluoro-pyridine-3-carbonyl)-amino)-pentyl)-ureido)-pentanedioic Acid - 2-(3-{1-Carboxy-5-[(6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic Acid - Fluorine F 18 DCFPyL - PIFLUFOLASTAT F-18 - Piflufolastat F 18 - Piflufolastat F-18 - Piflufolastat F18 - Pylarify