Alpha-Hydroxyglutarate

**Semantic type:** Organic Chemical

**Definition:** The base form of alpha-hydroxyglutaric acid, which is an intermediate in the synthesis of alpha-ketoglutaric acid. Alpha-hydroxyglutarate accumulates in the blood of patients with 2-hydroxyglutaric aciduria; an organic acid metabolism disorder, which is caused by the genetic mutation of one of the enzymes responsible for the conversion of 2-hydroxyglutaric acid to alpha-ketoglutaric acid.

**Synonyms:** - 2-HG - 2-Hydroxy-Pentanedioic Acid - 2-Hydroxyglutarate - 2-Hydroxyglutaric Acid - 2-Hydroxypentanedioic Acid - 2HG - Alpha-Hydroxyglutaric Acid - Pentanedioic Acid, 2-Hydroxy-