Procollagen-Proline Dioxygenase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** A tetrameric enzyme complex that catalyzes the post-translational formation of 4-hydroxyproline in the amino acid sequence -Xaa-Pro-Gly-, which is found in collagens and other proteins. The enzyme complex is comprised of two alpha chains and two beta chains. There are 3 separate genes that encode 3 distinct alpha proteins, prolyl 4-hydroxylase subunit alpha-1, -2 and -3. The beta chain is protein disulfide-isomerase.

**Synonyms:** - Collagen Proline Hydroxylase - EC 1.14.11.2 - Hydroxylase, Collagen Proline - P4H - Peptidyl Proline Hydroxylase - Procollagen-Proline 4-Dioxygenase - Proline Hydroxylase - Proline Protocollagen Hydroxylase - Proline, 2-Oxoglutarate Dioxygenase - Proline,2-Oxoglutarate 4-Dioxygenase - Prolyl 4-Hydroxylase - Prolyl Hydroxylase - Prolyl-Glycyl-Peptide, 2-Oxoglutarate:Oxygen Oxidoreductase, 4-Hydroxylating - Prolylprotocollagen Dioxygenase - Prolylprotocollagen Hydroxylase - Protocollagen Hydroxylase - Protocollagen Proline 4-Hydroxylase - Protocollagen Proline Dioxygenase - Protocollagen Proline Hydroxylase - Protocollagen Prolyl Hydroxylase