SERPINA3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SERPINA3 wild-type allele is located in the vicinity of 14q32.1 and is approximately 33 kb in length. This allele, which encodes alpha-1-antichymotrypsin protein, plays a role in the negative regulation of the activity of both neutrophil cathepsin G and mast cell chymase. Mutation of the gene is associated with alpha-1-antichymotrypsin deficiency and occlusive cerebrovascular disease. Genetic polymorphisms may be associated with increased susceptibility to either Alzheimer disease or Parkinson disease.

**Synonyms:** - AACT - ACT - Antichymotrypsin, Alpha-1 Gene - Cell Growth-Inhibiting Gene 24/25 - GIG24 - GIG25 - Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 Gene - Serine (Or Cysteine) Proteinase Inhibitor, Clade A, Member 3 Gene - Serine Proteinase Inhibitor, Clade A, Member 3 Gene - Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 3 wt Allele