Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** An autoinflammatory syndrome of childhood which often resolves in adolescence, and is characterized by periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. The fever cycle generally occurs every three to five weeks, and during the interim periods the child appears healthy; diagnosis is exclusionary.

**Synonyms:** - Marshall Syndrome - Marshall Syndrome - PFAPA Syndrome - PFAPA Syndrome