EGFR-GRB2 Complex

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A protein complex comprised of two epidermal growth factor receptor (EGFR) family proteins, and one or two growth factor receptor-bound protein 2 (GRB2) adaptor proteins. These complexes form after epidermal growth factor (EGF) family ligands bind to EGFR proteins. Ligand binding triggers receptor dimerization and cross-receptor tyrosine phosphorylation, which allows the SH2 domains of each growth factor receptor-bound protein 2 to form a non-covalent bond with the phosphorylated EGFR proteins.

**Synonyms:** - EGFR-GRB2 Signaling Complex - EGFR:GRB2 Complex - EGFR:GRB2 Signaling Complex - GRB2-EGFR Complex - GRB2:EGFR Complex