Nabilone

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity. Although the mechanism of action has not been fully elucidated yet, it has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea.

**Synonyms:** - Cesamet - Cesamet - Cpd 109514 - NABILONE