Tusamitamab Ravtansine

**Semantic type:** Pharmacologic Substance

**Definition:** An immunoconjugate consisting of anti-carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) conjugated to a cytotoxic agent, with potential antineoplastic activity. Upon administration of tusamitamab ravtansine the antibody moiety targets CEACAM5 on tumor cells. Upon antibody/antigen binding and internalization, the immunoconjugate releases the cytotoxic agent, which results in tumor cell death. CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types.

**Synonyms:** - ADC SAR408701 - Anti-CEACAM5 Antibody-Drug Conjugate SAR408701 - SAR408701 - TUSAMITAMAB RAVTANSINE