HPV 16 E7 Antigen-expressing Lactobacillis casei Vaccine BLS-ILB-E710c

**Semantic type:** Immunologic Factor|Pharmacologic Substance

**Definition:** An orally available Lactobacillis casei (L. casei)-based vaccine expressing the human papillomavirus (HPV) type 16 isoform E7 protein linked to the poly-gamma-glutamate synthetase complex gene pgsA, with potential immunostimulating activity. Upon oral administration, the expressed HPV 16 E7 may stimulate the immune system to mount a mucosal cytotoxic T-lymphocyte (CTL) response against HPV 16 E7-expressing tumor cells. The poly-glutamic acid synthetase PgsA from Bacillus subtilis acts as an anchoring motif that facilitates the expression of the HPV antigen protein on the surface of the bacteria. HPV 16 E7, a cell surface glycoprotein and tumor associated antigen, is overexpressed in various viral-related cancers.

**Synonyms:** - BLS-ILB-E710c - BLS-ILS-E710c - L. casei-E7 BLS_ILB_E710c - L.casei-PgsA-E7 - LacE7 Vaccine