IDH2 NP_002159.2:p.R140X

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the amino acid residue at position 140 in the isocitrate dehydrogenase [NADP], mitochondrial protein where arginine has been replaced by another amino acid. Mutations at this position are found in patients with acute myeloid leukemia following myelodysplastic syndromes and is associated with shorter overall survival.

**Synonyms:** - IDH2 Arg140Xxx - IDH2 R140 - IDH2 R140 - IDH2 R140 Mutation - IDH2 R140X - IDH2 p.Arg140Xxx - IDH2 p.R140 - Isocitrate Dehydrogenase 2 (NADP+) Mitochondrial Arg140Xxx - Isocitrate Dehydrogenase 2 (NADP+) Mitochondrial R140X - Isocitrate Dehydrogenase [NADP], Mitochondrial Arg140Xxx - Isocitrate Dehydrogenase [NADP], Mitochondrial R140X - NP_002159.2:p.Arg140Xxx - NP_002159.2:p.R140X