Oltipraz

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.

**Synonyms:** - 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl- - 3H-1,2-Dithiole-3-thione,4-methyl-5-pyrazinyl - 4-Methyl-5-(pyrazinyl)-3H-1,2-dithiole-3-thione - 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione - 5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thione - 5-[2-Pyrazinyl]-4-methyl-1,2-3-thione - OLTIPRAZ - RP-35,972 - oltipraz