Tilarginine

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A pan-nitric oxide synthase (NOS) inhibitor, with potential immunomodulating and antineoplastic activities. Upon administration, tilarginine binds to and inhibits NOS, a free radical signaling molecule that promotes angiogenesis, metastasis, and immunosuppression in the tumor microenvironment (TME). Reduction in NOS activity may abrogate the immunosuppressive TME, enhance tumor antigen-specific immune response and inhibit tumor cell proliferation.

**Synonyms:** - L-NMMA - MMA - Monomethylarginine - N-Methylarginine - N5-(Methylamidino)-L-ornithine - NG-Monomethyl-L-Arginine - NG-monomethyl-L-arginine - NMA - TILARGININE - Targinine - omega-N-Monomethylarginine