PDX1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human PDX1 wild-type allele is located in the vicinity of 13q12.1 and is approximately 6 kb in length. This allele, which encodes pancreas/duodenum homeobox protein 1, is involved in transcriptional regulation of insulin and other pancreatic genes. Mutation of the gene is associated with pancreatic agenesis, susceptibility to early-onset insulin-dependent diabetes mellitus, and maturity onset diabetes of the young type 4.

**Synonyms:** - GSF - IDX-1 - IPF1 - IUF1 - Insulin Promoter Factor 1, Homeodomain Transcription Factor Gene - MODY4 - PAGEN1 - PDX-1 - Pancreatic and Duodenal Homeobox 1 wt Allele - STF-1