Ranpirnase

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A natural homologue of ribonuclease A isolated from the eggs of the frog Rana pipiens. Ranpirnase primarily degrades cellular transfer RNA with a substrate specificity for uridine-guanidine base-pair sequences, resulting in inhibition of protein synthesis and cytotoxicity. This agent also activates caspase-9 in mitochondria, resulting in tumor cell apoptosis. (NCI04)

**Synonyms:** - Onconase - Onconase - P-30 - P-30 Protein - P-30 Protein - P-30 protein - P30 - P30 Protein - RANPIRNASE - RANPIRNASE