KRAS Activating Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the nucleotide sequence of the KRAS gene that results in constitutive signal transduction, which stimulates downstream signaling pathways involved in cell growth, proliferation, invasion, and metastasis. The presence of KRAS activating mutations in colorectal cancer and non-small-cell lung cancer is used identify the subgroup of patients who are most likely to respond to EGFR antagonist chemotherapy.

**Synonyms:** - Activating KRAS Mutation - KRAS Gene Activation - KRAS Proto-Oncogene, GTPase Activating Mutation - KRAS-2 Activating Mutation - KRAS2 Activating Mutation - c-K-ras Activating Mutation - v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Activating Mutation