Anti-Notch3 Antibody-drug Conjugate PF-06650808

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed against the neurogenic locus notch homolog protein 3 (Notch3) receptor conjugated to an auristatin-based cytotoxic payload, with potential antineoplastic activity. Upon administration of anti-Notch3 ADC PF-06650808, the antibody moiety targets and binds to Notch3 expressed on tumor cells. Upon binding and internalization, the auristatin-based cytotoxic agent binds to tubulin and inhibits its polymerization, which results in G2/M phase arrest and induces apoptosis of Notch3-expressing tumor cells. Notch3 is overexpressed on a variety of cancer cells.

**Synonyms:** - Anti-Notch3 ADC PF-06650808 - PF 06650808 - PF-06650808 - PF06650808