NGFR-transduced Autologous T Lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous, genetically modified T-lymphocytes that are expressing the tumor-associated antigen (TAA) nerve growth factor receptor (NGFR; p75 neurotrophin receptor; p75(NTR); CD271), with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the NGFR-transduced autologous T-lymphocytes may induce an immune response and may kill NGF-expressing tumor cells. Dysregulated NGF signaling may promote proliferation and invasion in certain tumor cell types.