Neuropathy, Hereditary Sensory and Autonomic, Type IV

**Semantic type:** Disease or Syndrome

**Definition:** A rare, autosomal recessive inherited disorder caused by mutations in the NTRK1 gene. It is characterized by inability to feel pain and temperature that leads to repeated unintentional self-injuries, and decreased or absent sweating that leads to hyperpyrexia and febrile seizures.

**Synonyms:** - CIPA - Congenital Insensitivity to Pain with Anhidrosis - HSAN4 - Hereditary Sensory and Autonomic Neuropathy Type IV