FOXO Family

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A subfamily within the forkhead box (FOX) protein family, which is a family of transcription factors that contain a forkhead DNA-binding domain. FOXO proteins regulate apoptosis, cell-cycle progression, oxidative-stress resistance, and tumor suppression. The transcriptional promoter activity of these factors is regulated by post-translational modifications, such as phosphorylation, acetylation, and monoubiquitination.

**Synonyms:** - FOXO - Fork Head Box Transcription Factor Class O - Forkhead Box Transcription Factor Class O - FoxO