Aggresome

**Semantic type:** Cell Component

**Definition:** A ubiquitin-rich cytoplasmic inclusion encased in vimentin found near the microtubule organizing center. It is formed in response to cellular stresses that cause the production of misfolded proteins at levels that exceed the degradative capacity of the proteasome. This inclusion body is comprised of aggregated misfolded or denatured proteins that have been transported along microtubules to the pericentriolar space where they become encased in vimentin.