Gallium Ga 68 Gozetotide

**Semantic type:** Amino Acid, Peptide, or Protein|Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radioconjugate composed of a human prostate specific membrane antigen (PSMA)-targeting ligand, Glu-urea-Lys(Ahx) (Glu-NH-CO-NH-Lys(Ahx)), conjugated, via the acyclic radiometal chelator N,N'-bis [2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-N,N'-diacetic acid (HBED-CC), to the radioisotope gallium Ga 68, with potential use as a tracer for PSMA-expressing tumors during positron emission tomography (PET). Upon intravenous administration of the gallium Ga 68 gozetotide, the Glu-urea-Lys(Ahx) moiety targets and binds to PSMA-expressing tumor cells. Upon internalization, PSMA-expressing tumor cells can be detected during PET imaging. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.

**Synonyms:** - (68)Ga labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC - (68)Ga-PSMA Ligand Glu-urea-Lys(Ahx)-HBED-CC - (68)Ga-labeled Glu-urea-Lys(Ahx)-HBED-CC - (68)Gallium-PSMA Ligand Glu-urea-Lys(Ahx)-HBED-CC - (68Ga)Glu-urea-Lys(Ahx)-HBED-CC - 68Ga-DKFZ-PSMA-11 - 68Ga-HBED-CC-PSMA - 68Ga-PSMA - 68Ga-PSMA-11 - 68Ga-PSMA-HBED-CC - 68Ga-labeled Glu-NH-CO-NH-Lys(Ahx)-HBED-CC - AAA 517 - AAA-517 - AAA517 - GA-68 PSMA-11 - GALLIUM GA-68 GOZETOTIDE - Ga PSMA - Ga-68 labeled DKFZ-PSMA-11 - Ga-68 labeled PSMA-11 - GaPSMA - Gallium Ga 68 PSMA-11 - Gallium Ga 68-labeled PSMA-11 - Gallium-68 PSMA - Gallium-68 PSMA Ligand Glu-urea-Lys(Ahx)-HBED-CC - PSMA-HBED-CC GA-68 - [68Ga] Prostate-specific Membrane Antigen 11 - [68Ga]GaPSMA-11