Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome

**Semantic type:** Disease or Syndrome

**Definition:** An autoinflammatory disease caused by mutations in the TNFRSF1A gene coding for tumor necrosis factor receptor 1 (TNFR1). This results in attacks of fever, rash, peritoneal, pleural, or pericardial serositis and/or synovial inflammation along with increased acute phase reactants. Complications may include amyloidosis.

**Synonyms:** - Familial Hibernian Fever - Familial Hibernian Fever - TNF Receptor 1-Associated Periodic Syndrome - TNF Receptor 1-Associated Periodic Syndrome - TRAPS - TRAPS