Pimonidazole

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Organic Chemical|Pharmacologic Substance

**Definition:** A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells, reduced pimonidazole binds to thiol-containing proteins. The resulting complexes accumulate in hypoxic tumors, thereby depleting radioprotective thiol compounds and sensitizing tumor cells to be more susceptible for radiation treatment.

**Synonyms:** - 1-piperidineethanol, alpha-((2-nitro-1h-imidazol-1-yl)methyl)- - PD 126675 - PIMONIDAZOLE - Ro 03-8799