Poly ICLC

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A synthetic complex of carboxymethylcellulose, polyinosinic-polycytidylic acid, and poly-L-lysine double-stranded RNA. Poly ICLC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the tumoricidal activities of various immunohematopoietic cells. (NCI04)

**Synonyms:** - HILTONOL - Hiltonol - Poly I:Poly C with Poly-L-Lysine Stabilizer - PolyI:PolyC with Poly-L-Lysine Stabilizer - Polyinosinic-Polycytidylic Acid Stabilized with Polylysine and Carboxymethylcellulose - Polyriboinosinic-Polyribocytidylic Acid-Polylysine Carboxymethylcellulose - Stabilized Polyriboinosinic/Polyribocytidylic Acid - poly-ICLC